Pwytter is another great Stand Alone Twitter Client that can be run from a Portable USB Device. Some key Pwytter features include: Timeline switch, Friends and Followers list, Easy Replies and Direct Messages, In message URL detection, Automatic and manual refresh and more. Pwytter is also available in 14 languages.

Pwytter – Stand Alone Twitter Client

Authors Website: pwytter.com

License: Open Source

How to make Pwytter Portable:

1. Download the Setup Pwytter exe
2. Download Universal Extractor and unRaR it's contents to a folder on your desktop
3. (1) Drag and Drop setup_pwytter_0.8.exe onto UniExtract.exe (2) Click OK
4. Move the setup_pwytter_0.8/{app} folder from your desktop to your USB device
5. Click pwytter.exe from the {app} folder to run the program